Search results for "Streptomyces coelicolor immobilization"

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Improvement of actinorhodin production yield in Streptomyces coelicolor by immobilized-cell cultivations by using PCL- and PLA-based films

2016

Actinomycetes are Gram-positive bacteria producing most of naturally occurring antibiotics (Donadio et al., 2010). At industrial level, antibiotics are produced by submerged fermentations where the actinomycete filamentous morphology negatively affects bioproductivity (van Dissel et al., 2014). Microporous membranes for bacterial cell-immobilization were already proven increasing bioproductivity in Streptomyces coelicolor, that is a model actinomycete producing the blue pigmented actinorhodin (ACT) antibiotic (Scaffaro et al., 2016). To develop an immobilized-cell bioreactor system, different kinds of polycaprolactone (PCL) and polylactic acid (PLA) films were produced by an electrospinning…

Settore ING-IND/22 - Scienza E Tecnologia Dei MaterialiStreptomyces coelicolor immobilizationbioproduction improvementpolycaprolactone and polylactic acid filmSettore BIO/19 - Microbiologia Generale
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IMPROVED PRODUCTION OF THE ANTIBIOTIC ACTINORHODIN IN STREPTOMYCES COELICOLOR IMMOBILIZED-MYCELIAL CELL CULTIVATIONS

2017

Objectives i) Evaluation of ACT production in Streptomyces coelicolor M145 mycelial cells immobilized on polycaprolactone (PCL) and polylactic acid (PLA) nanofiber membranes, modified or not by an O2- plasma treatment. ii) Identification of gene products associated with the improvement of ACT production.

Streptomyces coelicolor immobilizationO2-plasma treatmentnanofiber membraneactinorhodin productionSettore BIO/19 - Microbiologia Generaledifferential proteomic analysis.
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